Yes. To run the same service (e.g. SFTP, FTPS, or FTP) on multiple domains, you can either:

1. Use a different network interface/IP address for each service, e.g. SFTP on Domain 1 uses 192.168.100.103 and SFTP on Domain 2 uses 192.168.100.104.

2. Use a different port number (this is less common and might confuse users) for each service, e.g. SFTP on Domain 1 uses port 22 and SFTP on Domain 2 uses port 2222

Exception:

There is however, an exception. All HTTP/S services, regardless of domain, run on the same port number and network interface/IP address. They will all take the IP address/port number settings in Server > Settings > Web > Web tab > HTTP or HTTPS on host